Researchers found that when teenage girls are exposed to secondhand smoke at home, they tend to have lower levels of the "good" form of cholesterol that reduces heart disease risk.
High-density lipoproteins (HDL) pick up excess cholesterol in the blood stream and take it to the liver where it can be broken down, they said.
Unlike low-density lipoproteins that can create a waxy build-up that blocks blood vessels, HDL cholesterol can play a key role in combating heart disease risk.
"Secondhand smoke did not have the same impact on teenage boys of the same age, which suggests passive smoking exposure may be more harmful to girls. Considering cardiovascular disease is the leading cause of death in women in the western world, this is a serious concern," said Le-Ha.
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Researchers studied a longitudinal birth cohort of 1,057 adolescents who were born between 1989 and 1992 in Perth, Australia.
During that time, 48 per cent of the participants were exposed to secondhand smoke at home. Blood tests were performed to measure the teenagers' cholesterol levels.
"The findings indicate childhood passive smoke exposure may be a more significant cardiovascular risk factor for women than men," Le-Ha said.
The study was published in the Journal of Clinical Endocrinology and Metabolism.