The "Boardwalk Empire" made the revelations in an interview with Vanity Fair.
The first instance, de la Huerta said, was in November of that year. Weinstein allegedly offered her a ride home to her apartment, where he demanded to come inside and have a drink.
She said Weinstein then started to kiss her, and after she tried to brush him away, he pushed her onto the bed.
"I felt afraid... It wasn't consensual... It happened very quickly..." De la Huerta said.
The actor said the second assault happened a month later, in December.
De la Huerta joins dozens of women who have come out against Weinstein alleging sexual harassment or assault.