Pence's visit today is billed as a tour that includes Minot's launch facility for intercontinental ballistic missiles. He's also scheduled to address service members.
Defence Secretary James Mattis toured the base in September, in a visit widely seen as a reminder to North Korea of US nuclear capabilities.
Minot has one of the nation's two B-52 bomber bases and is home to the 91st Missile Wing, which operates 150 of the Air Force's 450 Minuteman 3 nuclear missiles.