The 32-year-old actress said she loves how the legendary director takes her mind off difficult scenes with his own worries, reported Contactmusic.
"He is such a hypochondriac, I have to laugh at him. In 'Vicky, Cristina, Barcelona' on the day Scarlett Johansson and I were to share a screen kiss, he had to leave the set to go to see a dermatologist because he had just seen a new freckle that morning.
"I said, 'Why don't you go this evening when we have finished shooting?' He said, 'It might be too late by then. That made me laugh so much, I couldn't be nervous about the kissing scene," she said.
Cruz is also looking forward to reunite with her "Bandidas" co-star Antonio Banderas for another film, "Los Amantes Pasajeros", directed by Pedro Almodovar.
"I've known Antonio for so long, since we were both living in New York 20 years ago. We were neighbours and we've been friends since - he, his wife, and family, and me and my family. We only have about two or three scenes together, but we're very excited about them," she said.