The 40-year-old 'Nine' star is the 11th woman to be given the title by Esquire magazine.
Actress Scarlett Johansson bagged the title last year.
Other actress to have won the spot previously are Angelina Jolie, Rihanna, Charlize Theron and Halle Berry.
The model-actress, who has recently finished filming for her upcoming film 'Ma Ma', said she does less work now as she is busy taking care of her family.