"Please, you have tested us enough, you have punished us enough. Free yourself from AIADMK rule," he said addressing a well attended public meeting organised by his party.
Apparently referring to electoral debacles his party suffered at the hands of arch-rival AIADMK since 2011 when his party lost power in Tamil Nadu, he wanted the people to elect DMK again.
Recalling a slew of infrastructure projects launched during the erstwhile DMK regime, he slammed the AIADMK regime, terming it "dormant" and "ineffective".
"Tamil Nadu is a state without a Chief Minister. She is not doing her job since she is not well and that is why she should take rest," he said.
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In a message read out by Finance Minister O Panneerselvam at the Iftar, she had said that she could not attend the event due to a sudden illness.
The following day Karunanidhi had said that the state government should formally provide details of Jayalalithaa's illness as people would be interested in knowing it.
Karunanidhi today said that information related to the Chief Minister should be transparent, he said, adding however it was not so in Tamil Nadu.
He also alleged that former Chief Minister and present Finance Minister O Panneerselvam is being harassed by AIADMK.
"He will weep if he visits me in private," he said.