Third seed Pallikal began well only to falter at key moments later in the title clash held yesterday, going down 8-11, 11-6, 12-10, 11-7 against the fourth seed.
Success in the WSA International 25 event in its fourth year at the Granite Club marks Perry's eighth WSA World Tour title - and her first ever win over Pallikal, the world No.13 from Chennai, in three meetings since October 2011.
World No.16 Perry made it to her 11th Tour final after overcoming top seed and defending champion Amanda Sobhy - ranked six places higher - in the semi-finals.
Perry maintained the momentum in the third, racing to a 6-2 lead. But 23-year-old Pallikal fought back to level at 10-10, before Perry clinched the game 12-10.
Pallikal twice led in the fourth at 6-5 and 7-6 - but the Indian number one was unable to fend off Perry, who took five points in a row on the way to her triumph, and her second Granite Open title since 2013.