Lions will be banking on captain Alviro Petersen, veteran Neil McKenzie, leggie Imran Tahir and left-arm seam duo of Lonwabo Tsotsobe and Pakistani speedster Sohail Tanvir to take them through to the semis.
Petersen will be partnered by Gulam Bodi who has had the experience of spending time in the dug-out of IPL team Delhi Daredevils. The duo will be followed by limited overs specialist Quinton de Kock and experienced McKenzie.
This will be the first time that both Scorchers and Lions will be up against each other in the short history of Champions League T20.
The Lions, in last year's campaign, had beaten Mumbai Indians, CSK and Delhi Daredevils on their road to final while in the 2010-11 tournament, they had beaten Mumbai Indians and Guyana but failed to progress ahead.
Perth Scorchers had a forgettable inaugural season last year, registering just one victory, apart from being besieged by off-field problems.