The network announced "Nobody Love" hitmaker Tori Kelly, rapper ASAP Rocky and musical duo Twenty One Pilots will also play at the event which will be aired on August 30, reported Entertainment Weekly.
The singers join Abel Tesfaye, popularly known by his stage name The Weeknd, who will give the first televised performance of his chart-topping hit "Can't Feel My Face".
Rapper Kanye West would receive the Video Vanguard Award during the show, and is expected to perform in support of the honour as well.
Additional performers will be announced later.
Pop star Miley Cyrus will host the award show.