Pietersen will represent Quetta Gladiators in the PSL.
The dashing batsman posted a photo of him on Instagram, hugging his son before leaving to join the Gladiators in Dubai.
"Countless goodbyes to Jessica Taylor and my kids as a cricket player and this one this evening is the last one I'll ever have to do. I've hated every goodbye but also known it's work so just gotten on with it," Pietersen said, hinting that the end is near.
"Cricket has been the best!" he said.
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The batsman has guided Quetta to the finals of the first two PSL but last year didnt travel to Lahore last March for the title clash, citing security concerns by his family.
Quetta Gladiators owner Nadeem Omar has said that Pietersen had also expressed his unwillingness to travel to Pakistan for the two play-off matches and final in Lahore and Karachi next month.
The batsman was sidelined by the England and Wales Cricket Board (ECB) in 2012 and again in 2014 after differences with the team management.
Omar said Pietersen had played a big role in Quettas surge as a top team in the PSL.
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