The study in the UK has found a clear link between high levels of bisphenol A and the clogging up of the arteries that supply heart with oxygen-rich blood.
Bisphenol A, a building-block of many commonly-used plastics, has been linked to heart disease before, the 'Daily Mail' reported.
The latest study, from Exeter University and its Peninsula Medical School, hints at how it might damage the heart.
However, other experts pointed out that the study falls short of proving it is the chemical that causes the damage.
They claimed as we are mainly exposed to bisphenol A through contaminated food and drinks, it is possible that those who have the most of it in their systems eat food that is bad for the heart.
Bisphenol A is described as a gender-bending chemical because it is a manmade version of the female sex hormone oestrogen.
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It is has recently been banned from baby feeding bottles but it is still used in a host of everyday plastic items, including cutlery, water bottles CD cases and sunglasses.
It is found in till receipts and used to line tin cans and has previously been linked to fertility problems, breast cancer and prostate cancer.
In the latest study, almost 600 men and women gave a urine sample and had the health of their coronary arteries measured.
As many as 385 were found to have severe narrowing of the arteries, 86 had moderate disease and 120 had normal coronary arteries.
The blood samples analysis showed that, on average, levels of bisphenol A were almost 20 per cent higher in people whose coronary arteries were badly clogged, the journal PLoS ONE reported.
"Our latest study suggests a growing body of work which suggests that bisphenol A may be adding to known risk factors of heart disease," said lead researcher Professor David Melzer.