The social media star passed away on Thursday evening after she was hospitalized for a blockage in her carotid artery on Monday, reported People magazine.
The blockage resulted in a stroke that left her in critical condition.
"It is with heavy hearts that we confirm the passing today of Katie May-mother, daughter, sister, friend, businesswoman, model and social media star-after suffering a catastrophic stroke caused by a blocked carotid artery on Monday.
"Katie was a star in every sense of the word and I'll never stop missing her," May's brother, Stephen, said in a statement.
"Anyone who was lucky enough to know Katie May was truly blessed by her incredible heart, mind and soul. She was an inspiration and a guiding light to so many people in this world," the donation page reads.