The Joint Investigation Team (JIT) chief Wajid Zia had summoned the prime minister to appear before the six-member probe team today with all documents relevant to the case.
Ahead of his deposition befor the JIT, Sharif held consultations with his close aides and family members this morning.
It is expected that finance minister Ishaq Dar will accompany him to the deposition.
Sharif has already barred his party activists from join him or receiving him at the Judicial Academy in Islamabad where he would be questioned.
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In its judgement of April 20 in the Panama Papers case, the Supreme Court had constituted a JIT and empowered it to summon the prime minister, his sons and any other person necessary, to investigate allegations of money-laundering, through which the four apartments in London's posh Park Lane area were purchased.
Sharif has denied any wrongdoing.
The Joint Investigation Team had questioned Sharif's sons -- Hussain and Hasan -- last month over the family's alleged improper business dealings.
The court last year took up the case and issued a split decision over allegations of money laundering when Sharif was prime minister in 1990s.
On May 5, the Supreme Court set up a high-level six- member JIT to probe Sharif and his sons' alleged corruption in the Panama Papers case.
The JIT is bound to complete the probe in 60 days unless it is granted additional time.
It is for the first time that a sitting prime minister would appear before a high-level probe team traditionally constituted to investigate high-profile criminal cases.
Media reports had also said that Finance Minister Ishaq Dar may also be questioned today by the JIT before Sharif's appearance.
The JIT probing the offshore holdings of Prime Minister Sharif and his children has also summoned his younger brother and Punjab Chief Minister Shahbaz Sharif, to appear before it on June 17.