Police in an upscale suburb of Minneapolis went to check on the family after no one was seen or heard from in days, South Lake Minnetonka Interim Chief Mike Siitari told The Associated Press.
Siitari wouldn't release any information on how the family members died but said there appeared to be "no threat or danger to the community."
The children had not been in school for the past two days, Siitari said. The request to check on the family came from a co-worker of the father, he said.
Siitari said the Hennepin County Sheriff's Office was processing a "complex crime scene."
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Aerial footage from KSTP-TV showed an upscale home in Greenwood, a village of about 700 people on the shore of Lake Minnetonka, west of Minneapolis. At the scene, police officers had sealed off Channel Drive, a wooded cul de sac leading toward St. Alban's Bay on the lake.
A sign at the entrance to the cul de sac read "Children playing." The family's house wasn't visible beyond the police line.
An online biography at the site said Short lived outside Minneapolis with his wife and three children.
The biography describes Short as a one-time nursing student and entrepreneur who built and launched the website in the late 1990s when he couldn't find nursing-related information online.
An administrator of AllNurses.Com posted a notice Thursday night saying that the family had been killed and calling it "a very tragic loss for the extended families, friends, co-workers, and this nursing community.