Police Chief John Mina also said the shooter had some sort of "suspicious device." He said the suspect exchanged gunfire with an officer working at the club around 2 AM., then went back inside and took hostages.
Around 5 AM, authorities sent in a SWAT team to rescue the hostages, and the suspect then died in a gunfight with those officers. Mina said police have not determined an exact number of casualties, but that "approximately 20" people were dead inside the club.
"This is an incident, as I see it, that we certainly classify as domestic terror incident," said Orange County Sheriff Jerry Demings.
Police had said previously on Twitter that there was a "controlled explosion" at the scene of the shooting at Pulse Orlando. Mina said that noise was caused by a device intended to distract the shooter.
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"The next text said: 'He has us, and he's in here with us,'" she said. "That was the last conversation."
Dozens of police vehicles, including a SWAT team, swarmed the area around the club. At least two police pickup trucks were seen taking what appeared to be shooting victims to the Orlando Regional Medical Center.
Police said local, state and federal agencies were investigating.