"During the operation, the five terrorists were neutralised after they resisted armed force, and four security forces were lightly injured," the governor's office said in a statement.
Police also seized weapons during the raid including five Kalashnikovs, a gun and ammunition.
The raid took place as part of an investigation into whether the suspects were planning to target events commemorating last year's failed coup on July 15, Dogan news agency said.
The statement did not say whether the five had actually been planning an attack.
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Turkey has been hit by a series of attacks in the last 18 months blamed on IS and Kurdish militants.
In a report published on Tuesday, the interior ministry said there had been 14 major terrorist attacks conducted by IS including 10 suicide bombings, one bomb attack and three armed attacks.
The attacks had killed 304 people, including 10 police officers and one soldier.
The last major IS attack was during New Year's Eve celebrations at an elite Istanbul nightclub where a gunman killed 39 people, most of them foreigners.
Last week, President Recep Tayyip Erdogan claimed Turkey had killed 3,000 IS terrorists during its operations against the group in northern Syria which ran from August until March
He also said Turkey had deported 5,000 terror suspects and banned another 53,000 people from entering the country.