Professor Francois Bochud of the Lausanne Institute of Applied Radiophysics said his team measured levels of polonium up to 20 times higher than it was used to detecting in its research.
"By definition, that indicates third party involvement," Bochud told reporters. "Our results offer moderate backing for the theory of poisoning."
The lab's probe could not say for sure whether Arafat was killed by polonium, however.
"We can't say that polonium was the source of his death... Nor can we rule it out," said Bochud, whose institute is part of Switzerland's respected Vaudois University Hospital Centre.
Arafat died in a hospital near Paris on November 11, 2004.