Before leaving Ecuador's capital Quito, Francis was to meet with the elderly and give a pep talk to local clergy.
Then he was set to fly to La Paz and meet with Bolivian President Evo Morales, an Aymara Indian known for his anti-imperialist and socialist stands.
The stop in La Paz was being kept to four hours to spare the 78-year-old pope from the taxing 4,000-metre elevation; the rest of his Bolivian stay will be in Santa Cruz.
Their shared views on caring for society's poorest, and the need for wealthy countries to drastically change course to address climate change have bumped up against Morales' anti-clerical initiatives that have roiled relations with the local church.
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As soon as Morales took office in 2006, for example, the Bible and cross were removed from the presidential palace.
A new constitution in 2009 made the overwhelmingly Catholic nation a secular state and Andean religious rituals replaced Catholic rites at official state ceremonies.
"The church is also questioning some decisions made about development in the country."
Morales, who expelled the US ambassador and Drug Enforcement Administration, came to power championing Bolivia's 36 indigenous groups and enshrined their rights in the constitution.
But he has alienated lowlands natives by promoting a highway through a nature reserve and authorizing oil and natural gas exploration in wilderness areas.