He will be offering a show of solidarity with Cubans and making clear that Hispanics in the United States are the bedrock of the American church.
The visit boasts several firsts for history's first Latin American pope: Francis will become the first pope to address the US Congress and he will also proclaim the first saint on US soil by canonizing the controversial (and Hispanic) missionary, Junipero Serra.
It's largely unknown territory for the 78-year-old Argentine Jesuit, who has never visited either country and confessed that the United States was so foreign to him that he would spend the summer reading up on it. His popularity ratings are high in the U.S., but he also has gained detractors, particularly among conservatives over his critiques of the excesses of capitalism.
But Francis has also been on record criticizing Cuba's socialist and atheist revolution as denying individuals their "transcendent dignity.