Local authorities estimated some 150,000 people turned out at Yangon's Kyaikkasan Ground park for the Mass, but the crowd seemed far larger.
Catholics had to apply to attend through their local churches to enter the park venue, and many dressed in matching outfits or with hats bearing the pope's image.
Before Mass, Francis looped around the park in his open- sided popemobile, waving to the crowds that continued to pour in as the service began. Local government officials and senior members of Aung San Suu Kyi's National League for Democracy party were on hand, as were members of Myanmar's mostly Christian Kachin minority, wearing traditional dress.
His trip has been overshadowed, though, by Myanmar's military operations targeting the Rohingya Muslim minority in northern Rakhine state.
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The crackdown, which has been described by the UN as a campaign of "textbook ethnic cleansing," has drawn international condemnation.
In his first public comments yesterday, Francis told Suu Kyi and other government authorities that Myanmar's future lay in respecting the rights of all its people -- "none excluded" -- but he refrained from mentioning the "Rohingya" by name.
In his homily today, Francis referred to the suffering that Myanmar's ethnic and religious minorities have endured, a reference to the decades of conflicts between Myanmar's ethnic minorities and the military that continue today in parts of the country.
Myanmar recently emerged from nearly a half-century of military dictatorship, but minorities including the Kachins are still subject to discrimination and other forms of violence.
"I know that many in Myanmar bear the wounds of violence, wounds both visible and invisible," Francis told the crowd in Italian that was translated into Burmese. While the temptation is to respond with revenge, Francis urged instead a response of "forgiveness and compassion."
Later today, Francis is to meet with Myanmar's Buddhist leadership and then speak to the country's Catholic bishops. He celebrates a Mass for young people tomorrow and then heads to Bangladesh for the second leg of his South Asian tour.
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