The Argentine pope will meet Christians and Muslims forced to leave their homes and flee to the neighbouring desert kingdom, now home to more than 600,000 refugees and the first stop on Francis' trip ahead of Israel and the Palestinian territories.
He will pray with the refugees and hundreds of disabled youths, cancer patients and orphans at Wadi al-Kharrar on the eastern bank of the river Jordan, where many Christians believe Jesus was baptised by John the Baptist.
"He needs to see the situation of Christians in Syria. He needs to see what terrorism did to them and to their heritage," said Norma, 30, from the ancient Christian settlement of Maalula, recently recaptured from rebels by President Bashar al-Assad's forces.
"In the past we lived in harmony and coexistence, but now Syrian Christians are in danger," she said, reflecting the view of many Christians -- Roman Catholic and Orthodox -- who sided with Assad, fearing the harsh Islamist ideology of some rebel factions.
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In all, some 450,000 Syrian Christians have been displaced by the conflict since it began in March 2011, according to Gregory Laham, Syrian Patriarch of the Melkite Greek Catholic Church.
Father Rifat Bader, spokesman for the papal visit to Jordan, said Francis' trip would be a show of support for Christians across the region.
"Christian brothers from Syria and Iraq have fled violence and religious persecution. Christians in the region have become under threat since the war on Iraq in 2003."