Francis issued the marching orders during the ceremony in St Peter's Basilica to elevate the new "princes of the church" into the College of Cardinals.
Retired Pope Benedict XVI was on hand for the ceremony, sitting off to the side in the front row of the basilica, in a unique blending of popes past, present and future.
Many of the new cardinals hail from far-flung, often overlooked dioceses and many are pastors, who like Francis have focused their ministry on the poor.
In his homily, Francis reminded them that being a cardinal isn't a prize or fancy entitlement, but rather a way to serve the church better in humility and tenderness.
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He warned them that not even churchmen are immune from the temptation to be jealous, angry or proud, or to pursue their own self-interests, even when "cloaked in noble appearances."
"Even here, charity, and charity alone, frees us," he said. "Above all it frees us from the mortal danger of pent-up anger, of that smoldering anger which makes us brood over wrongs we have received. No. This is unacceptable in a man of the church."
Then, he ticked off 15 ailments including "spiritual Alzheimer's" and the "terrorism of gossip," that can afflict men of the church even at its highest levels.
This is Francis' second consistory creating new cardinals and once again he looked to the "peripheries" to give greater geographic representation to the Europe-centric College of Cardinals.
His choices, though, also reflect his vision for what the church should be: One that looks out for the poor and most marginalised, guided by shepherds who have what he has called the "smell" of their sheep.
Another is Cardinal Francesco Montenegro of Agrigento, Sicily, whose church -- which extends to the island of Lampedusa -- has coped with the arrival of tens of thousands of migrants over the years.