And he called for religious freedom to be upheld throughout a region ravaged by war and bloodshed, where a dwindling Christian population faces daily persecution.
As he walked off the plane onto a red carpet at Amman airport, his white robes flapping in the hot desert wind, he was greeted by officials and two children dressed in traditional costume who handed him bouquets of irises, the national flower of Jordan.
At a stadium in the city, where Francis will celebrate an afternoon mass, thousands of people were packing into blue and red chairs in front of a large altar, behind which hung posters of John Paul II and John XXIII, who were made saints this month.
"Lasting peace for the entire region... Requires that a peaceful solution be found to the crisis in Syria, as well as a just solution to the Israeli-Palestinian conflict," the pope said at the royal palace, ahead of a meeting with Syrian refugees.
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Syria's civil war, which began in 2011, is estimated to have claimed at least 162,000 lives and forced another 2.7 million people to flee to neighbouring countries, 450,000 of them Christians.
Later today, Francis was to head to a site on the River Jordan where many believe Jesus was baptised by John the Baptist. There he will hear first-hand accounts of the suffering in Syria from some of the 600,000 refugees hosted by Jordan.
The 77-year-old pontiff also urged respect for religious freedom in a region where the Holy See called for an end to the ongoing persecution of Christians.
"Religious freedom is, in fact, a fundamental human right and I cannot fail to express my hope that it will be upheld throughout the Middle East and the entire world," he said.