At the Wanderers stadium, after losing the three-ODI series 2-0, the visitors will be looking to make their first mark on the tour, in what will be a new era in the annals of Indian cricket.
For this is the first Test match for Team India following the retirement of Sachin Tendulkar. The Master Blaster bid farewell after playing his 200th Test versus West Indies in Mumbai, in what was an emotional roller-coaster for the entire nation's cricket fans.
The first question to be asked is who will bat at number four? The true realisation of Tendulkar's departure will dawn when a new face comes in to bat at the fall of the second wicket during India's first innings in this Test.
It probably will be Virat Kohli, attempting to fill in the big boots, an unenviable task surely.
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They lost a series to England in between. Most importantly, this long home season ensured the transition with Tendulkar, Rahul Dravid and VVS Laxman departing the scene.