Prabhu said he was "extremely pained by the unfortunate accidents, injuries to passengers and loss of precious lives".
"I met the the Hon'ble Prime Minister @narendramodi taking full moral responsibility. Hon'ble PM has asked me to wait," Prabhu tweeted.
He said in less than three years as the railway minister, he had devoted his "blood and sweat" to the Railways.
"Undr leadership of PM, tried 2 overcome decades of neglect thru systemic reforms in all areas leading 2 unprecedented investment and milestones," he said in a series of tweets.
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