The Bengaluru-based startup already operates in 15 countries including Singapore, Indonesia and Philippines across over 50 cities.
It currently lists over 2 lakh doctors, 10,000 hospitals, 8,000 diagnostic centres and over 4,000 wellness centres globally and receives over 10 million searches monthly across its website and apps.
"Practo will start with Sao Paulo and will bring two of its products - Practo Search and Practo Ray (cloud based practice management solution for doctors) to the market. They will be available in Portuguese and English for consumers and healthcare professionals in Brazil," Practo said in a statement.
They can go through the Practo Profile for each professional or establishment as well.
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Through Practo's app and website, consumers will be able to search through over 5,500 verified doctors, which covers nearly 50 per cent of all clinics in Sao Paulo, it said.
In the second half of 2016, Practo plans to expand to Rio de Janeiro and eventually to all large cities in Brazil.
Additionally, Practo will also expand its consumer offering to cover more healthcare segments such as wellness, fitness, preventive and curative segments as well, it said.
"We are thrilled to have the opportunity to serve millions of consumers in Brazil and simplify healthcare experience for doctors and consumers simultaneously," Shashank ND, Founder & CEO, Practo said.