He will also unveil Golden Jubilee logo and present the President's Police Medals for Distinguished Services besides the DP Kohli Award for the Best Detective Constable of the agency.
The agency had come into being on April 1, 1963 through a Home Ministry notification which converted erstwhile Special Police Establishment into CBI as need was felt for it to not only probe bribery and vigilance cases but also those panning across state and national boundaries.
Mukherjee will also honour former Directors of CBI.
"The prestigious DP Kohli Memorial lecture is organised annually by the CBI in the honour of its founder Director. Late Kohli was the Head of Special Police Establishment and Central Bureau of Investigation from 1955 to 1968," CBI spokesperson said in a statement.
The agency will also identify future challenges and formulate a plan to build capacity to meet these.