The scholarly President, who was a college teacher and a journalist before he plunged into the hurly burly of politics in 1969, will hold a joint class for grade XI and XII students of Dr Rajendra Prasad Sarvodaya Vidyalaya at the school located inside the Presidential Estate.
An aide said the President will tell them about political history "as he has seen unfolding".
The students will assemble on the 'Knowledge floor' and listen to their new teacher. Later, the President will address nearly 100 teachers also.
79-year-old Mukherjee has Masters degree in History and Political Science as also Law from the University of Kolkata.
A voracious reader, Mukherjee has often stressed on the need for providing quality education and, in his address to the nation on the eve of Independence Day earlier this month, had laid special emphasis on "guru-shishya" (Teacher-Student) relations.