Starting with a meeting in Washington DC with workers from a landmine clearance charity supported by his mother late Princess Diana, the 28-year-old plans to meet members of the Halo Trust, of which he is a patron.
He is later scheduled to visit the US capital's Arlington Cemetery to pay respects to those killed in recent conflicts before travelling on to Colorado.
During the trip, which will also cover New York, Captain Harry Wales will attend the Warrior Games, a sporting championship for injured servicemen and women.
"Although a prince, Harry is also an operational soldier -- indeed he's a soldier's soldier -- therefore throughout this briefing the recurring theme is to help recognise and bring a spotlight on to the work being done to help these outstanding young men and women."
Also Read
The Apache helicopter pilot, Harry, will also support British interests and promote his own charities.
This is his first return to the US since being pictured naked in Las Vegas in 2012, after he had reportedly been playing "strip billiards" with friends in his hotel room for a private party.
He will be escorted by Senator John McCain around the display, which features images of landmine victims and workers clearing ordnance and former landmine sites.
In New York, he will support the Great Campaign, a government initiative which promotes the UK around the world.
Harry is also scheduled to attend a baseball event as he promotes a sports programme involving his Royal Foundation.