The first official tour as a couple since the fifth in line to Britain's throne announced his engagement to the 36- year-old American actress earlier this week was greeted by large crowds who cheered the royals.
The couple plan will spend the day at a World AIDS Day charity fair organised by the Terrence Higgins Trust and then meet Headteachers of a local school, Nottingham Academy.
"Prince Harry and Meghan Markle are in Nottingham for their first official visit together since announcing their engagement," Kensington Palace said in a statement on Friday.
A year later, he established the Full Effect programme, which aims to stop youth violence in the city in the Midlands region of England.
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The prince's communication's secretary, Jason Knauf, said the prince was looking forward to introducing his 36-year-old bride-to-be to a community that had "become very special to him".
He added that Markle, best known for her role as Rachel Zane in the legal drama 'Suits', "could not wait" to meet people she had heard so much about.
In the lead up to the wedding, Markle would not be continuing her work as an actress or on gender with the United Nations and other organisations and instead would start new charity work as a full-time royal. She plans to focus her attention on the UK and Commonwealth.
"This is the country that's going to be her home now and that means travelling around, getting to know the towns and cities and smaller communities," their spokesperson said.
She will also become the fourth patron of the Royal Foundation of the Duke and Duchess of Cambridge and Prince Harry.
It has also been announced that Markle intends to become a British citizen and will work towards it in the coming years.