Shops, business establishments, offices and petrol pumps were shut in Srinagar and elsewhere in the Valley while government offices and banks witnessed thin attendance, officials said.
They said public transport was off the roads in the city and across the major towns in the Valley with only some private cars, cabs and auto-rickshaws plying on a few routes.
Work in courts was also affected due to the strike.
The strike call was also endorsed by hardline Hurriyat Conference chairman Syed Ali Shah Geelani, who termed the recent reprinting of the sketches of the Prophet in France as "Jewish journalistic hooliganism" and asked people to hold protests against the act.
"Any act of dishonour against the Prophet of Islam (SAW) is unacceptable for every Muslim of the world and to raise voice against this act is the matter of faith for every Muslim," Geelani said in a statement yesterday.