The protesters sought to march on the Sur neighbourhood of the southeastern city of Diyarbakir -- which has been under an almost constant curfew since December 2 -- but were halted by a police barricade.
The police fired tear gas cannisters and water cannon, sparking chaotic scenes as protesters sought to flee the streets amid clouds of smoke, an AFP photographer said.
The pro-Kurdish protesters meanwhile threw stones at the security forces, the photographer added. Protesters sought to kick the tear gas cannisters away to prevent being overcome.
According to the Turkish military, a total of 15 Kurdish militants have been killed in the Sur neighbourhood since the offensive began, including eight yesterday alone.
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In the town of Cizre in Sirnak province, which has been under curfew since early last week, 103 Kurdish militants have been killed.
It is not possible to independently verify the figures. A Turkish soldier was also killed yesterday in Sur, according to the army.
The PKK launched a formal insurgency against the Turkish state in 1984, initially fighting for Kurdish independence although it now presses more for greater autonomy and rights for the country's largest ethnic minority.
The conflict has left tens of thousands dead.