Researchers from the US-based Center for Disease Dynamics, Economics and Policy (CDDEP) collected samples from 530 birds in 18 poultry farms in Punjab and tested them for resistance to a range of antibiotic medications critical to human medicine.
Two-thirds of the farms reported using antibiotic factors for growth promotion, according to the researchers.
Dr A C Dhariwal, director of National Centre for Disease Control, said antibiotic resistance is a public health concern in India for which a national programme called containment of antimicrobial resistance has been launched.
Samples from the farms, which reported using antibiotic factors, were three times more likely to be multidrug- resistant than samples from farms that did not use antibiotics to promote growth, the researchers said.
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The team found reservoirs of resistance across both types of farms but meat farms had twice the rates of antimicrobial resistance that egg-producing farms had, as well as higher rates of multidrug resistance.
They also found high levels of multidrug resistance, ranging from 39 per cent for ciprofloxacin, used to treat endocarditis, gastroenteritis, cellulitis and other infections, to 86 per cent for nalidixic acid, a common treatment for urinary tract infections.
"This study has serious implications, not only for India but globally," said Ramanan Laxminarayan, director at CDDEP.
"Overuse of antibiotics in animal farms endangers all of us. We must remove antibiotics from the human food chain, except to treat sick animals, or face the increasingly real prospect of a post-antibiotic world," he added.
Use of antibiotics for growth promotion in farm animals has increased worldwide in response to rising demand for food animal products, researchers said.
The study was published in the journal Environmental Health Perspectives.