President Vladimir Putin on Wednesday said Russia would have to deploy missiles targeting "decision-making centres" if Washington sends missiles to Europe.
The announcement comes after the US said it would withdraw from a key Cold War-era arms treaty over what it said were Russian violations, prompting a mirror move from Moscow.
"Russia does not intend to be the first to deploy such missiles in Europe," Putin said during an annual state of the nation address.
"If (the US) develops and deploys them in Europe... this will dramatically exacerbate the international security situation, creating serious threats to Russia," he said.
"I'm saying this clearly and openly, Russia will be forced to deploy weapons that can be used... against the decision-making centres that are behind the missiles systems which threaten us."