The airline has been battling record fuel costs and fierce competition from subsidised rivals and in December said 1,000 jobs would go while warning it faced a half-year loss of up to 300 million Australian dollars.
The interim result is due on Thursday and the Sydney Daily Telegraph, citing a Qantas source, said the job losses would be much worse as the airline restructures its finances to convince the government it deserves a debt guarantee.
The airline refused to go into details.
"There is fresh speculation about what things we will or won't announce on Thursday as part of our half-year results. We are not in a position to comment on that speculation," the flag carrier in a statement.
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"We have said that we will be making some tough decisions in order to achieve $2 billion in cost savings over the next three years, which is a consequence of an unprecedented set of market conditions now facing Qantas."
Qantas has said it was facing "immense" challenges and has been lobbying the government to ease limits in foreign investment or provide state intervention to help shore up its bottom line.
Qantas chief Alan Joyce argues that the cap is hurting Qantas's ability to compete by restricting access to capital, particularly against domestic rival Virgin Australia, which is majority-owned by state-backed Singapore Airlines, Air New Zealand and Etihad.
Following its profit warning in December, Moody's and S&P both downgraded Qantas' credit rating to "junk" status, increasing the cost of financing for the carrier and restricting access for investors that do not put their money in lower-rated companies.
"We've said that we must take steps to reduce our costs regardless of whether the federal government acts on the uneven playing field in the Australian aviation market," said the statement.