Priyanka, 35, shared the news with fans on Twitter and welcomed Matlin on board.
"Welcome to #quantico @MarleeMatlin we can't wait to have u on board," Priyanka wrote.
Matlin, who is best known for her performance of a young deaf woman, Sarah Norman, in "Children of a Lesser God", also expressed her excitement by tweeting, "Can't wait to work with Priyanka Chopra, Johanna Braddy, Jake Mclaughlin, my old friend Blair Underwood and of course Michael Seitzman."
Matlin, 51, has joined "Quantico" as a series regular for the upcoming third season.