The nearly three-week battle for Qusayr in central Syria exposed the central role played by Lebanese Shiite movement Hezbollah, a key Assad backer.
Analysts believe the group's fighters, who are experienced in guerrilla warfare, will remain engaged wherever the regime needs them.
The regime has "the advantage right now" while the rebels are "losing morale", said Shadi Hamid of the Brookings Doha Center.
"What Qusayr confirms is that the regime's fall is not inevitable and in fact, the rebels might actually lose," analyst Hamid told AFP.
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Thousands of fighters, civilians and injured people evacuated the town, most of them to a nearby insurgent-held village.
"On a psychological level, this is very important, not just for Syria but for the international community," said Hamid. "In any peace conference or negotiations, it puts the regime at an advantage."
The international community has been pushing since last month for a US-Russian peace initiative dubbed Geneva 2 that aims to end the two-year conflict by bringing rebels and regime representatives to the negotiating table.
Now, the rebels are "reluctant to go to Geneva. This is the worst time for them to sit at the negotiating table because they have less leverage today than they have had in months," said Hamid.
The regime is meanwhile seeking to "cleanse key cities Aleppo (in the north), Damascus and Homs (in the centre) before any international conference is held", said Naji Malaeb, a military analyst at the Dubai-based Inegma centre.
Qusayr lies at a key juncture between regime stronghold Damascus and the coastline, a bastion of the Alawite community to which Assad's clan belongs.
The town is also important "because it lies on a rebel supply route" from majority Sunni areas in northern Lebanon to Homs in central Syria, noted Malaeb.