The 40-year-old actor made his Bollywood debut with "Aamir" and went on to work in films like "Shaitan", "Soundtrack" and "Table No 21".
Khandelwal was last seen on big screen in the 2014 film "Samrat & Co".
"I don't think life is only about work. Sometimes the scripts don't excite me sometimes the films don't work out. I don't prefer working just for the sake of it," Khandelwal told reporters.
"I don't get stressed that 'Oh I am not doing anything, I'll vanish from public eye. It doesn't really bother me," he added.
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"Gemma embodies hotness. People who have seen her work will agree to that. To add to the fact, I am a big fan of football and she is Ronaldo's ex-girlfriend. So, that is how I started knowing about her," the director said.
Jhaveri then approached Italian actress Murino, who appeared in the 2006 James Bond film "Casino Royale" as Solange Dimitrios.
"There cannot be a bigger romance for a spy than to romance a Bond girl. I sent Caternia the script and she was gracious enough to accept it.
Produced by Ajay Chabbria, "Fever" is scheduled to release on July 22.