The second singles of the tie will be between Saketh Myneni and world number 13 David Ferrer, according to the draw announced by the International Tennis Federation today.
On the second day, experienced Leander Paes will pair up with Saketh to face French Open champions Feliciano Lopez and Marc Lopez.
In the reverse singles, it will be Saketh's turn to clash with Nadal, while Ramanathan will lock horns with Ferrer.
"We are used to playing in different conditions but here the humidity is higher than even during the seasons. So we need to be fit and with best of five sets in this conditions, it will be hard. We need to adapt to the conditions and be prepared for the start."
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"I'm really excited to play one of the best players of all time. We have to keep the first few games close and play some aggressive tennis. I need to play with a lot of forehand and attack his forehand, play as deep as possible and ofcourse serve well. I am ready to play my heart out," Ramanathan said.
India and Spain have locked horns thrice so far in Davis Cup with the European nation leading the head-to-head record 2-1. The last time India played Spain was as far back as 1965 when they lost the away tie 2-3.
"We are the underdogs and we have to find a way to do well, put everything on line and bled blue on the court. If we can finish 1-1 after day 1, we will have a good chance. So everything depends on first day," Saketh said.