McGowan, who was seen tearing up while recounting her experience, said Hollywood and Bollywood were "propaganda machines" set up by men in power.
The outspoken American actor is among the 50 women who levelled allegations of sexual harassment, assault and in some cases rape against Weinstein after the New York Times and The New Yorker exposed a 30-year saga of exploitation.
"Rape is theft. I was stolen. My life was stolen. It is a crime. For years, I became a passenger in my own body. And I am not the only one because after every #MeToo out there, there is a #IDidIt," she said at the HT Leadership Summit here.
After the expose on Weinstein, several other powerful men in Hollywood, including actors, filmmakers, journalists, comedians and talk show hosts, faced similar accusations.
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The 44-year-old actor, best known for her TV show "Charmed" and the film "Scream", said, "I believe this is a huge floodgate opening that will extend to the judicial process...
"I think the mindset is changing. I work in a heavily male-dominated field. It is not just the firing... When you strip them of the power, in their mind it is the worst thing."
"I try not to see myself through the gender lens that much but the world focuses on that. I have been through 20 years of playing with the big boys and they don't play nice.
"For me to affect cultural change, which is what I wanted for the last 20 years, I had to work very hard to stay alive long enough to get there. I had to go around the system sideways to get there," she said at the
Asked a specific question about Weinstein, she said people in the media are equally complicit in propagating a false narrative.
"He bought a lot of them off and they ran a very false narrative that affected women all over the world.
"It is so important that we see through it and see what the propaganda machine is telling us," she added.
"It is not just a Hollywood problem, this is upper management problem at all levels. It is anybody with power and who abuses it," she said.
The actor said there was need to break the circle of "exclusionary practices" that keep women out of power.
"In a house, there is a woman running a family, would it not follow that she would be effective in running a board room. It is just the exclusionary practices. You just need to look at people for their skill set."
"I would love everyone to get us being beyond male and female and get us back to humanity. The only way we can do this is to address things, have real conversations and I just wanted to have a conversation with the world so let us.... I know we can change things, I believe in us," she said.
The session also included speakers Dr Rola Hallam, who works in war-ravaged Syria, and Farah Mohamed, an advocate for girls' rights and the CEO of Malala Fund.