The 59-year-old star has joined Robert De Niro, Al Pacino and Joe Pesci in the film, which is based on the book by Charles Brandt, "I Heard You Paint Houses: Frank 'The Irishman' Sheeran and the Inside Story of the Mafia, the Teamsters, and the Final Ride by Jimmy Hoffa", according to The Hollywood Reporter.
The film begins shooting next month in and around New York and will continue through December.
Harvey Keitel and Bobby Cannavale are in various stages of dealmaking to board the Netflix feature.
Romano will play Bill Bufalino, a Teamster lawyer with ties to the mob.
The actor previously worked with Scorsese when he starred on the HBO series "Vinyl".
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