Fresh from Daniel Ricciardo's maiden win in Canada two weeks ago, the Austrian team will have home advantage at the Red Bull Ring amid the rolling hills of southern Styria.
But the 24-year-old Australian still has a large gap to close if he is to catch up with current championship leader Nico Rosberg and his teammate Lewis Hamilton, who stand respectively at 140 and 118 points, to his 79.
This will not happen again, Mercedes team chief Toto Wolff vowed ahead of F1's return to the historic track at Spielberg: "We will be pushing harder than ever to ensure that we do not give away any more valuable points to our rivals."
"We know we cannot afford to slip up as our rivals are always there to take advantage," added Rosberg.
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For Red Bull, the 1-3 finish in Montreal was a perfect set-up for this weekend's race.
But Vettel, third in Canada and fifth in overall standings, was confident that racing on home ground on Sunday "will energise us."
"I have been looking forward (to this race) since the start of the season. A Grand Prix on the Red Bull Ring is a very special motivation for our team."
"We will fight with all we've got to stand on top of the podium," he promised.
- Home asphalt -
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Another team to be claiming home advantage will be Toro Rosso -- also owned by the Austrian energy drink maker.
Lotus, Caterham and Marussia, on the other hand, will just be hoping to redeem themselves after seeing all their drivers retire in a crash- and accident-packed race two weeks ago.