The 38-year-old star, who is starring in 'Don't Mess With Texas' with Vergara, 41, posted pictures of them on Instagram and captioned one of them as 'workwife', reported Female First.
"Happy Friday with Sofia Vergara," the actress captioned a picture of the two in costumes, adding the hashtags #workwife #happywifehappylife.
Alongside one picture of Vergara leaning in to apply her friend's make-up, Witherspoon wrote, "Thanks for the makeup Sofia Vergara... Now can you do my hair?"
Vergara, who is in New Orleans with Reese for the shoot - posted a similar photo.