The "Wild" star launched her Southern-inspired lifestyle line in May and now fans can check out her wares in the actress' hometown.
"I am so proud!!!," Witherspoon wrote on Instagram.
"The first ever @draperjamesgirl store is officially open in #Nashville!! 2608 12th Avenue South!"
The 39-year-old actress added a photo of the shop's exterior, which boasts a white and bright blue striped wall, along with the Draper James logo.
The store was made to resemble a Southern home, decked out in bright colours and floral prints. Witherspoon even hired interior designer Mark Sikes, who is working on the actress' home, to create the feel of a house "rooted in tradition".