Oscar-nominated screenwriter Nick Hornby is penning the script based on the true-life tale of Strayed's journey to traverse the 1,100-mile Pacific Crest Trail alone after her mother died, her family fractured and her marriage failed, all at the age of 22.
Witherspoon will also produce the picture along with Bruna Papandrea and River Road Entertainment's Bill Pohlad, reported Deadline.
"Nick's innate blend of humanity and humor are a perfect match for Cheryl's raw emotional memoir. I look forward to collaborating with both of these talented writers to create a film full of honesty, adventure and self discovery," said Witherspoon.