Former general Shwe Mann, a key architect of reforms since the end of the junta in 2011, has long been tipped for a tilt at the nation's top office -- currently held by Thein Sein.
"I will run for president because it is the key post to work for the betterment of the country and the people's interest," he told Radio Free Asia's Myanmar service during a visit to Washington yesterday, according to a report on their website.
Incumbent Thein Sein is yet to indicate if he will stand in the 2015 polls, anticipated be a milestone in Myanmar's transformation from an authoritarian nation to democracy.
Suu Kyi last week said she would run for president, although the existing military-drafted constitution bars her from the office.
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"I want to run for president and I'm quite frank about it," the veteran democracy activist told delegates at the World Economic Forum (WEF) on East Asia in the capital Naypyidaw.
Her National League for Democracy (NLD) party swept by-elections in 2011, causing soul-searching among the army-linked ruling Union Solidarity and Development Party of Thein Sein and Shwe Mann with general elections edging closer.
Shwe Mann told RFA that Myanmar's parliament will soon establish a commission to review the constitution, and will abide by its recommendations, including any that say Nobel Laureate Suu Kyi should be allowed to run for president.
"If the commission submits proposals, including the possibility of Daw (honorific) Aung San Suu Kyi being able to contest as president, then parliament will support work on it," Shwe Mann said.
The role nevertheless made him one of the highest profile figures in the new regime.
He is credited by MPs with helping to foster political debate in a parliament that critics derided as toothless when it opened in January 2011.