Over 95 per cent of voters who flocked to the polls in the northern regions of Veneto and Lombardy, home to Venice and Milan respectively, supported a mandate to negotiate a better deal with the Italian capital.
Turnout was higher than expected in the referendums held yesterday, and the results should not be underestimated in the context of the crisis created by Catalonia's push for independence, analysts warned.
Voter participation was 57 percent in Veneto and almost 39 percent in Lombardy.
The consultative votes are only the beginning of a process which could eventually lead to powers being devolved from Rome.
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The leaders of the two regions, which contribute up to 30 per cent of Italy's GDP, will now embark on negotiations with the central government on the devolution of powers and tax revenues.
Once the terms are agreed, they will need a green light from parliament in a process that could take up to a year.
"More than five million people voted for change. We all want less waste, fewer taxes, less bureaucracy, fewer state and EU constraints, more efficiency, more employment and more security," said LN head Matteo Salvini.
"We have given the whole of Europe a lesson in democracy. We have chosen the legal, peaceful, constitutional path," he said in reference to the Catalogna vote, which clashed with Spain's constitution.
The anti-establishment Five Star Movement (M5S), which is currently leading voter intention polls for next year's national elections, was quick to insist the result was "a citizen victory, certain not a Northern League one".
Secessionist sentiment in Veneto and Lombardy is restricted to fringe groups but analysts see the autonomy drive as reflecting the same cocktail of issues and pressures that resulted in Scotland's narrowly-defeated independence vote, Britain's decision to leave the EU and the Catalan crisis.
"Lombardy is not Catalonia, nor indeed is Veneto, but the revival of the autonomist flame here takes place in a Europe which tends towards fragmentation and closing in on itself," Italian political commentator Stefano Folli said.
"Following the populist wave, now Europe has also to face a nationalist/regionalist wave, which somewhat overlaps with the populist one, and makes European integration even more difficult," he added.
And Folli evoked the fear in Italy that the results, which "captured a growing divide between the North and South", could aggravate deeply rooted antipathies that predate the country's unification in the 19th century.
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