Liverpool can widen the chasm between themselves and Manchester United to a staggering 30 points if they come out on top in the battle between England's two most successful clubs at Anfield on Sunday.
Jurgen Klopp's men look destined to end a 30-year wait to win a top-flight title, with a 14-point lead over defending champions Manchester City plus a game in hand.
United are a further 13 points back, having also played a game more than their rivals, and in need of a strong end to the campaign to avoid failing to qualify for the Champions League for a second consecutive season.
Ole Gunnar Solskjaer's men are, however, the only side to have slowed Liverpool's relentless march towards the Premier League title.
The 1-1 draw between the teams in October was the only time the European champions have dropped points this season. They have now set a record for Europe's top five leagues, with 20 wins from their opening 21 games.
"Our team have a winning mindset. We always think about the next game, we don't look too far ahead," said Liverpool goalkeeper Alisson Becker, who has conceded just one goal in his past 10 games.
"We focus upon what is within reach at the time and we do everything possible to make sure we leave the pitch with a win and this has contributed to the great results this season."
- Watford warning for Spurs -
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- Last chance for Norwich -
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Fixtures
Saturday (1500 GMT unless stated)
Watford v Tottenham (1230), Arsenal v Sheffield United, Brighton v Aston Villa, Manchester City v Crystal Palace, Norwich v Bournemouth, Southampton v Wolves, West Ham v Everton, Newcastle v Chelsea (1730) Sunday