The former Secretary of State was projected to bag at least 56 delegates out of 107 at stake in North Carolina.
Clinton also won in Florida after having a massive lead over her sole rival Senator Bernie Sanders. Clinton had support of 65.6 per cent of the votes as against 30.6 per cent for Sanders.
Trump walked away with all the 99 delegates which were at stake in Florida.
It has been a "devastating" night for Rubio in Florida where he polled just 27.8 per cent of the votes as against Trump's impressive 45.3 per cent.
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"Word is that, despite a record amount spent on negative and phony ads, I had a massive victory in Florida," Trump said in a tweet even before major television channels projected his victory.
Being billed as Super Tuesday 2.0, primary elections were held in five States - Florida, Ohio, North Carolina, Illinois and Missouri.
However, in Ohio where 66 delegates are at stake, State Governor John Kasich was leading against Trump. Clinton was leading in Ohio.
The primary elections held in five states yesterday is part of the process of both the Republican and Democratic parties to nominate their presidential candidates for the November 8 elections, which would elect the next occupant of the White House.