Anadolu Agency said the two were detained in Sanliurfa province together with their suicide vests and explosives. There was no immediate information on their nationalities.
The arrests came a day after Istanbul police detained some 40 foreign nationals suspected of links to IS in simultaneous raids in the city's Fatih neighborhood.
Those detained included nationals from Azerbaijan, Iran, Iraq and Afghanistan, Anadolu reported, adding that some of them had traveled to conflict zones in Syria several times.
Turkey has suffered a wave of suicide bomb attacks blamed on IS since last year that have killed more than 200 people.